RayStation Announces Clinical Use With Boron Neutron Capture Therapy in Japan

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RaySearch Laboratories AB has announced that treatment planning system RayStation®* is now in clinical use with boron neutron capture therapy (BNCT) – along with treatment machine from Sumitomo Heavy Industries, Ltd. (SHI) – at two leading cancer clinics in Japan.

RaySearch announced in 2017 that it had entered into an agreement with Japanese manufacturer SHI regarding treatment planning for BNCT. The accelerator-based BNCT system and dose-calculation program from SHI obtained market clearance in spring 2020.

The advancement of BNCT as a form of radiation therapy is taking place at centers such as Osaka Medical College and Southern Tohoku Hospital. Accelerator-based BNCT is a relatively new method of delivering BNCT and facilitates an emerging hospital-based utilization of the BNCT modality.

Clinicians at Southern Tohoku General Hospital in Koriyama, Fukushima, treated the first patient with the combination of SHI’s BNCT treatment delivery equipment and RayStation on May 26, 2020. The clinical start at Osaka Medical College in Osaka followed shortly thereafter. The first clinical application concerns treatment of unresectable recurrent head and neck tumors and is covered by Japanese national health insurance since June 1, 2020.

BNCT uses a two-step process. Firstly, the patient is injected with a tumor-localizing drug containing the non-radioactive isotope boron-10. In the second step, the target area is exposed to a beam of low-energy neutrons, many of which are absorbed by the boron-10. The absorption initiates a reaction in which short-range, high-energy charged particles are emitted. These particles systematically destroy tumor cells with minimal damage to adjacent healthy tissue.

RayStation supports BNCT treatment planning for the SHI system with tools for contouring, image importing, plan creation and evaluation, and reporting.

Johan Löf, founder and CEO, RaySearch, (pictured above) says: “RaySearch exists to further advance cancer treatment through innovative software solutions designed to support cutting-edge medical equipment. Our cooperation with SHI and the resulting clinical use in Japan is a perfect example of how RayStation can support cancer treatment for most modalities and for a wide range of treatment devices”.

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RayStation Announces Clinical Use With Boron Neutron Capture Therapy in Japan.  Appl Rad Oncol. 

By News Release| November 24, 2020
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